राष्ट्रीय मलेरिया अनुसंधान संस्थान

+91-11-25307103 / 104            director@mrcindia.org

NIMR Field Unit: Chennai (Tamilnadu)

Chennai city reports 53.6% to 78.8% of the total malaria cases in Tamil Nadu. Plasmodium vivax is the predominant malaria parasite, which accounts for 93 to 96.3% of the cases.  In order to understand the transmission dynamics of malaria in an urban environment, a field unit was opened in July 1986. The primary objective of the field unit was to develop an eco-friendly, cost effective and sustainable intervention technology for control of Urban Malaria with Chennai as a role model. Ever since its inception, the field unit has carried out number of scientific/research projects. Bio-environmental control of malaria in Chennai and based on the successful field demonstration, ‘Seven point action plan for Malaria control’ was drafted and submitted to Govt. of Tamil Nadu in 1992; large scale field evaluation of bio-larvicides in two major water ways in Chennai, which was later on incorporated for mosquito control in Tamil Nadu; Malariogenic stratification to control malaria in Dindigul Municipality and this resulted in the development of GIS based Malaria Surveillance System; Bionomics of ecological variants of urban malaria vector, Anopheles stephensi in Chennai; Rainwater harvesting (RWH) and methods to mitigate mosquito/vector breeding in Chennai  are some of the major projects undertaken by the field unit. Besides, the field unit has evaluated many new larvicides and adulticides formulations, repellents and diagnostic kits, the results of which have been translated to the national programme. The field unit has identified a new larvivorous fish, Puntius sharmai in Chennai (1992), new sibling species of Anopheles culicifacies complex (Species E) in Rameswaram Island (1992) and confirmed the taxonomic ambiguity of indigenous larvivorous fishes, Aplocheilus parvus and A. blocki in Chennai (2007). All the research findings of the field unit are intended to strengthen the intervention operations of the local health authorities by providing necessary scientific inputs.  Field unit also provides technical support to the state/national programme by imparting training programme to Postgraduate/diploma students in medical laboratory technology, graduate and postgraduate students of medical colleges besides, arts and science colleges. Field demonstrations of entomological inspections are also imparted to entomologists and field staff. The field unit has carried out situation analysis and outbreak investigations for malaria in Tamil Nadu, Odisha and Kerala. Dengue and Chikungunya outbreak investigations were also carried out in Kerala and Tamil Nadu. Several workshops for Intersectoral Co-ordination for malaria control for engineers and public health officials of state and central government were undertaken. The research activities are carried out in close coordination with the Corporation of Chennai, Directorate of Public Health and Preventive Medicine, Govt. of Tamil Nadu and Regional Office for Health & Family Welfare, Govt.of India.

Research Staff

1. Dr. Alex Eapen, Scientist ‘D’ & Officer-in-Charge

2. Dr. K. John Ravindran, RO/Scientist B

3. Mr. N. Bhaskar, Technical Assistant

4. Ms. B. Reeta, Technical Assistant

Ongoing Research Projects

1. Center for the Study of Complex Malaria in India – NIH project (NIMR/PB/2010/150): Co-Investigator.

2. Ecology and distribution of Aedes albopictus and Ae. aegypti with special reference to albopictus subgroup species of the subgenus Stegomyia in Kerala, India (NIMR/IDVC/2011/ 128): Principal Investigator.

3. Monitoring of anti malarial resistance to Plasmodium vivax and P. falciparum malaria in endemic areas of Tamil Nadu, India (NIMR/IDVC/2013/223): Principal Investigator.

4. A comparative study on the susceptibility of Anopheles stephensi from geographically diverse ecotypes in Tamil Nadu to Plasmodium species (NIMR/IDVC/2013/224): Principal Investigator.

5. Dynamics of malaria in endemic areas of Chennai (Thiruvottriyur), Tamil Nadu, India (NIMR/ IDVC/2014/253): Principal Investigator.

6. Monitoring of existing intervention tools/methods in the programme for scaling down malaria in Rameswaram Island, Tamil Nadu, India (NIMR/IDVC/2014/254): Principal Investigator.

7. Effect of microclimate changes on vector density and its consequence to malaria transmission in Chennai, India: Principal Investigator.

8. Evaluation of SumiLarv 2 MR as a mosquito larvicide for control of Aedes aegypti in container habitats in Chennai, India- WHOPES project: Principal Investigator.

Technical Reports

1. Seven point action plan for malaria control in Madras city – MRC Tech Info. Series No.003/92.

2. Seven point action plan for malaria control in urban areas – MRC Tech Info. Series No.003/96.

3. Rainwater harvesting and methods to mitigate mosquito breeding in Chennai- 2003.

4. Entomological investigations on the suspected Chikungunya outbreak in Kerala – 2007.

Recent Research Publications (last 5 years)

Eapen Alex, Ravindran KJ and Dash AP (2010). Breeding potential of Aedes albopictus (Skuse, 1895) in Chikungunya affected areas of Kerala, India. Indian Journal of Medical Research 132: 733-735.

Raghavendra K, Ghosh SK, Eapen Alex, Tiwari SN, Satyanarayan TS, Ravindran KJ, Sreehari U and Dash AP (2011). Field evaluation of lambda-cyhalothrin (ICON 10 CS) indoor residual spraying against Anopheles culicifacies in India. Journal of Vector Borne Diseases 48: 18-26.

Tennyson S, Balaraju K, Park K, Ravindran KJ, Eapen Alex and William SJ (2011). In vitro antimicrobial activity of Ageratum houstonianum Mill. (Asteraceae). Food Science 35: 2897-2900.

Tennyson S, Ravindran KJ and Arivoli S (2011). Screening of plant extracts for ovicidal activity against Culex quinquefasciatus Say (Diptera: Culicidae). Applied Botany, 40: 5456-5460.

Lalneihpuia C, Ravindran KJ and William SJ (2011). Effect of plant oils on ovipositional activity of the vector mosquito Aedes aegypti (Diptera: Culicidae). Hexapoda, 18(1): 42-44.

Laneihpuia C, Ravindran KJ and William SJ (2011). Ovicidal activity of Eucalyptus oil against the dengue vector Aedes aegypti ((Diptera: Culicidae). Hexapoda, 18(1): 45-46.

Prajapathi SK, Joshi H, Shalini S, Patarroyo MA, Suwanarusk R, Kumar A, Sharma SK, Eapen Alex, Dev V, Bhatt RM, Valecha N, Nosten F, Rizvi MA and Dash AP (2011). Plasmodium vivax lineages: geographical distribution, tandem repeat polymorphism and phylogenetic relationship. Malaria Journal 10: 374.

Mallick PK, Joshi H, Valecha N, Sharma SK, Eapen Alex, Bhatt RM, Srivastava HC, Sutton PL, Dash AP, Bhasin VK (2012). Mutant Pfcrt “SVMNT” haplotype and wild type Pfmdr1 “N86” are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure. Malaria Journal, 11:16.

Das A, Anvikar AR, Cator LJ, Dhiman RC, Eapen Alex, Mishra N, Nagpal BN, Nanda N, Raghavendra K, Read AF, Sharma SK, Singh OP, Singh V, Sinnis P, Srivastava HC, Sullivan SA, Sutton PL, Thomas MB, Carlton JM and Valecha N (2012). Malaria in India: The Center for the study of Complex Malaria in India. Acta Tropica, 121: 267–273.

Sakthivadivel M, Eapen Alex and Dash AP (2012). Evaluation of toxicity of plant extracts against vector of lymphatic filariasis, Culex quinquefasciatus. Indian Journal of Medical Research, 135 (3): 397-400.

Ravindran J, Samuel T, Eapen Alex and William J (2012). Adulticidal activity of Ageratum houstonianum Mill. (Asteraceae) leaf extracts against three vector mosquito species (Diptera: Culicidae). Asian Pacific Journal of Tropical Disease, 2: 177-179.

Ravindran KJ, Daniel R, Kumari S, George S and Eapen Alex (2012). Effect of Agricultural Pesticides, Hostathion and Kitazin on the larvivorosity of the Carnatic Rice Fish, Oryzias carnaticus (Jerdon, 1849). American- Eurasian Journal of Toxicological Sciences, 4 (2): 56-59.

Tennyson S, Ravindran KJ, Eapen Alex and William J (2012). Repellent activity of Ageratum houstonianum Mill. (Asteraceae) leaf extracts against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Asian Pacific Journal of Tropical Disease, 2: 478-480.

Tennyson S, Balaraju K, Park K, Ravindran KJ, Eapen Alex and William J (2012). In vitro antioxidant activity of Ageratum houstonianum Mill. (Asteraceae). Asian Pacific Journal of Tropical Disease, 2: S712-S714.

Tennyson S, Ravindran KJ, Eapen Alex and William J (2012). Effect of Ageratum houstonianum Mill. (Asteraceae) leaf extracts on the oviposition activity of Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Parasitology Research, 111: 2295-2299.

Arivoli S, Ravindran KJ and Tennyson S (2012). Larvicidal efficacy of plant extracts against the malarial vector Anopheles stephensi Liston (Diptera: Culicidae). World Journal of Medical Sciences, 7(2): 77-80.

Arivoli S, Ravindran KJ, Raveen R and Tennyson S (2012). Larvicidal activity of botanicals against the filarial vector Culex quinquefasciatus Say (Diptera: Culicidae). International Journal of Research in Zoology, 2(1): 13-17.

Tennyson S, Ravindran KJ and Arivoli S (2012). Screening of twenty five plant extracts for larvicidal activity against Culex quinquefasciatus Say (Diptera: Culicidae). Asian Pacific Journal of Tropical Biomedicine, 2: S1130-S1134.

Tennyson S, Ravindran KJ and Arivoli S (2012). Bio-efficacy of botanical insecticides against the dengue and chikungunya vector Aedes aegypti (L.) (Diptera: Culicidae). Asian Pacific Journal of Tropical Biomedicine, 2: S1842-S1844.

Cator LJ, Thomas S, Paaijmans KP, Ravishankaran S, Justin JA, Mathai MT, Read AF, Thomas MB and Eapen Alex (2013). Characterizing microclimate in urban malaria transmission settings: a case study from Chennai, India. Malaria Journal, 12:84.

Gupta P, Pande V, Eapen Alex and Singh V (2013). Genotyping of MSP3β gene in Indian Plasmodium vivax. Journal of Vector Borne Diseases, 50: 197-201.

Shalini S, Chaudhuri S, Sutton PL, Mishra N, Srivastava N, David JK, Ravindran KJ, Carlton, JM and Eapen Alex (2014). Chloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India. Malaria Journal, 13: 129.

Venkatesan R, Ravindran J, Eapen Alex and William J (2014). Insecticidal and growth regulating activity of crude extracts of Cassia occidentalis L. (Caesalpinaceae) against the urban malaria vector, Anopheles stephensi Liston (Diptera: Culicidae). Asian Pacific Journal of Tropical Disease, 4 (2): S578-S582.

Tennyson S, Ravindran J, Eapen Alex and William J (2015). Ovicidal activity of Ageratum houstonianum Mill. (Asteraceae) leaf extracts against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Asian Pacific Journal of Tropical Disease, 5 (3): 199-203.

Tennyson S, Ravindran J, Eapen Alex and William J (2015). Larvicidal activity of Ageratum houstonianum Mill. (Asteraceae) leaf extracts against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae). Asian Pacific Journal of Tropical Disease, 5 (Suppl 1): S73-S76.

Conn JE, Norris DE, Donnelly MJ, Beebe NW, Burkot TR, Coulibaly MB, Chery L, Eapen Alex, Keven JB,  Kilama M, Kumar A, Lindsay SW, Moreno M, Quiñones ML, Reimer LS, Russell TL, Smith DL,  Thomas MB, Walker ED, Wilson ML and Yan G (2015). Entomological monitoring and  evaluation: Diverse  transmission settings of ICEMR will require local and regional Malaria  elimination strategies. American Journal of Tropical Medicine and Hygiene, 93 (Suppl 3), 28-41.

Quiñones ML, Norris De, Mzilahowa T, Conn JE, Moreno M, Burkot TR, Yan G, Rosas A, Palomino M,  Donnelly MJ, Mawajje HD, Eapen Alex, Coulibaly MB, Beier J, Kumar A (2015). Insecticide  resistance in areas under investigation by the International Centers of Excellence for Malaria  Research: A challenge for malaria control and elimination 2015. American Journal of Tropical  Medicine and Hygiene, 93 (Suppl 3), 69-78.

Wilson ML, Krogstad DJ, Arinaitwe E, Arevalo-Herrera M, Chery L, Ferreira MU, Daouda N, Mathanga DP and Eapen Alex (2015). Urban Malaria: Understanding its epidemiology, ecology and transmission risk across diverse ICEMR sites. American Journal of Tropical Medicine and Hygiene, 93 (Suppl 3), 110-123.

Nagpal BN, Ghosh SK, Eapen Alex, Srivastava A, Sharma MC, Singh VP, Parashar BD, Prakash Shri, Mendki MJ, Tikar SN, Saxena Rekha, Gupta Sanjeev, Tiwari SN, Ojha VP, Ravindran KJ, Ganesan K, Rao AN, Sharma RS, Tuli NR, Yadav NK, Vijayaraghavan R, Dua VK, Dash AP, Kaushik MP, Joshi PL and Valecha N (2015). Control of Aedes aegypti and Ae. albopictus, the vectors of dengue and chikungunya, by using pheromone C21 with an insect growth regulator: Results of multicentric trials from 2007-12 in India. Journal of Vector Borne Diseases 52: 224-231.

Dykes CL, Das MK, Eapen Alex, Batra CP, Ghosh SK, Vijayan VA, Mishra S and Singh OP (2016). Knockdown resistance (kdr) Mutations in Indian Anopheles stephensi populations. Journal of Medical Entomology, 1-6.

Contact details

National Institute of Malaria Research (ICMR),

NIE Campus, 2nd Main Road ,

TNHB, Ayapakkam,

Chennai- 600 077.

India.

Phones: 91-44-26820600 (Direct- Office), 91-44-26821700

Mobile:  +91 9444253592

 

सर्वाधिकार ©2015, राष्ट्रीय मलेरिया अनुसंधान संस्थान